Isotretinoin is a form of vitamin A that is primarily used to treat severe nodular or cystic acne that has not responded to other treatments, such as antibiotics. Brand names for isotretinoin include Absorica®, Accutane®, Amnesteem®, Claravis®, Myorisan®, Sotret®, and Zenatane™. Treatment with Isotretinoin often results in prolonged clearance of acne, which may be permanent for some patients. This medication is prescribed under a special program called iPLEDGE.